{"id":65022,"date":"2024-04-28T13:00:00","date_gmt":"2024-04-28T18:00:00","guid":{"rendered":"https:\/\/blogs.uninter.edu.mx\/ESCAT\/?p=65022"},"modified":"2024-03-15T11:46:10","modified_gmt":"2024-03-15T17:46:10","slug":"nanocristales-de-oro-contra-parkinson","status":"publish","type":"post","link":"https:\/\/blogs.uninter.edu.mx\/ESCAT\/index.php\/nanocristales-de-oro-contra-parkinson\/","title":{"rendered":"Nanocristales de Oro Pueden Revertir el D\u00e9ficit Neurol\u00f3gico del Parkinson #ESCAT #Uninter #Salud"},"content":{"rendered":"
\n
\"\"<\/a><\/figure>\n<\/div>\n\n\n

Los nanocristales de oro se han mostrado prometedores para revertir los d\u00e9ficits neurol\u00f3gicos en pacientes con esclerosis m\u00faltiple (EM) y enfermedad de Parkinson (EP).<\/p>\n\n\n\n\n\n\n\n

En los ensayos cl\u00ednicos, esta nanomedicina demostr\u00f3 la capacidad de resolver trastornos relacionados con la energ\u00eda en el cerebro de los pacientes.

Estos estudios cl\u00ednicos fueron realizados por investigadores del UT Southwestern Medical Center y los nanocristales se administraron a los pacientes regularmente durante 12 semanas. <\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

<\/p>\n\n\n\n

Energ\u00eda constante para las c\u00e9lulas<\/h2>\n\n\n\n

El funcionamiento \u00f3ptimo del cerebro humano depende de una variedad de factores.

Un factor importante es el suministro constante de energ\u00eda a las c\u00e9lulas cerebrales, al que contribuye una mol\u00e9cula fundamental conocida como trifosfato de adenosina (ATP).

Sin embargo, a medida que las personas envejecen, la capacidad del cerebro para metabolizar la energ\u00eda disminuye naturalmente. <\/p>\n\n\n\n

Los m\u00e9dicos suelen documentar esta disminuci\u00f3n a trav\u00e9s de una “disminuci\u00f3n en la proporci\u00f3n de nicotinamida adenina dinucle\u00f3tido (NAD+)” y su contraparte, “nicotinamida adenina dinucle\u00f3tido + hidr\u00f3geno (NADH)”.

NAD+ y NADH son coenzimas que participan en una variedad de funciones celulares, incluida la generaci\u00f3n de energ\u00eda. Desempe\u00f1an un papel importante en la conversi\u00f3n de nutrientes en ATP, la moneda energ\u00e9tica fundamental para las c\u00e9lulas.<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

<\/p>\n\n\n\n

Administrada por v\u00eda oral <\/h2>\n\n\n\n

El equipo de investigaci\u00f3n llev\u00f3 a cabo dos ensayos cl\u00ednicos de fase dos para probar el tratamiento experimental, denominado CNM-Au8, en pacientes.

En estos ensayos, se reclutaron 11 pacientes con EM recurrente y 13 con enfermedad de Parkinson.

Para establecer una l\u00ednea de base para cada participante, se realiz\u00f3 una espectroscopia de resonancia magn\u00e9tica (MR) cerebral inicial.<\/p>\n\n\n\n

Esta exploraci\u00f3n evalu\u00f3 la relaci\u00f3n inicial NAD+\/NADH, as\u00ed como los niveles de otras sustancias qu\u00edmicas asociadas con la energ\u00eda celular en el cerebro.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n\n\n\n

Despu\u00e9s de la evaluaci\u00f3n inicial, los individuos recibieron una dosis oral diaria de CNM-Au8 durante 12 semanas. <\/p>\n\n\n\n

Despu\u00e9s del per\u00edodo de tratamiento, se realiz\u00f3 una segunda exploraci\u00f3n por espectroscopia de RM para determinar cualquier cambio en la relaci\u00f3n NAD+\/NADH y otras mol\u00e9culas importantes.

Los hallazgos muestran que el medicamento revirti\u00f3 eficazmente las anomal\u00edas relacionadas con la actividad energ\u00e9tica, lo que result\u00f3 en mejoras funcionales notables.<\/p>\n\n\n\n

Fuente: Webconsultas<\/a><\/h6>\n\n\n\n

Ingenier\u00eda en Mecatr\u00f3nica<\/a>
M\u00e1s noticias sobre Mecatr\u00f3nica<\/a><\/p>\n\n\n\n

\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Los nanocristales de oro se han mostrado prometedores para revertir los d\u00e9ficits neurol\u00f3gicos en pacientes con esclerosis m\u00faltiple (EM) y enfermedad de Parkinson 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